SCREENING OF A FOCUSED UBIQUITIN-PROTEASOME PATHWAY INHIBITOR LIBRARY IDENTIFIES SMALL MOLECULES AS NOVEL MODULATORS OF BOTULINUM NEUROTOXIN TYPE A TOXICITY

Botulinum neurotoxins (BoNTs) are known as the most potent bacterial toxins, which can cause potentially deadly disease botulism.BoNT Serotype A (BoNT/A) is the most studied serotype as it is responsible for most human botulism cases, and its formulations are extensively utilized in clinics for therapeutic and cosmetic applications.BoNT/A has the l

Purpose - This study Tick Dips aims to determine the effect of each dimension of diamond fraud (pressure, opportunity, rationalization, capability) and personal ethics on the fraud tendency (assets misappropriation) and understanding of religiosity as moderating variable.Method - The study was conducted by survey method.The samples are amil zakat i

The research problem described in this article is related to the security of an IP network that is set up between two cities using hosting.The network is used for transmitting telephone traffic between servers located in Germany and the Netherlands.The concern is that with the increasing adoption of IP telephony worldwide, the Foot Balm network mig

Vandalism among young people is one of the urgent problems in the study of youth deviant behavior.Vandal activity arises as a result of the deformation of Stemless Wine Glass social interaction, which becomes fixed and turns into destructive actions of people trying to understand themselves in social space through this form of activity.The article